20-year-old midfielder Dan Batty makes his league debut for the Tigers as Nigel Adkins makes plenty of changes to his side on the final day of the season.
David Marshall, Seb Larsson and leading scorer Jarrod Bowen also come in, while Evandro is one of those included on the bench.
Brentford: Luke Daniels, Lewis MacLeod, Nico Yennaris, Josh McEachran, Kamohelo Mokotjo, John Egan, Emiliano Marcondes, Alan Judge, Josh Clarke, Yoann Barbet, Sergi Canos.
Subs: Daniel Bentley, Neal Maupay, Ollie Watkins, Ryan Woods, Chiedozie Ogbene, Tom Field, Mads Bech Sorensen.
Hull City: David Marshall, Ondrej Mazuch, Michael Hector, Jon Toral, Sebastian Larsson, Daniel Batty, Jarrod Bowen, Fraizer Campbell, Stephen Kingsley, Fikayo Tomori, Harry Wilson.
Subs: Callum Burton, Nouha Dicko, Evandro, Will Keane, Markus Henriksen, Ola Aina, Kevin Stewart.
Referee: Mr J. Linington.